Resolution not scaling properly

The assets and the game itself are all natively scaled to 1600 X 900, but some players are saying that when they play on larger resolution monitors (i.e., 2560X1600), the game’s scaling gets all messed up, even when full screen is enabled as well as automatic resolution scaling. Anyone have experience with this?

1600x900 does not scale into 2560x1600.

They are not even divisors on each other. Meaning the scaling will always be a decimal based number and will have to make up half pixels.

Edit: You might need to show your project properties so people can see exactly what settings you are using, along with any events for changing resolution.