Should i scale sprites or use their original resolution?

Hi, i am using low resolution in general like 640360 but still there is some not detailed sprites like blocks etc that can be made easily at 1616 pixel (smaller size and still same sprite) but its small for gameplay i need 6464 pixel blocks, should i scale it in drawing app and use it as 6464 or use it as 16*16 pixel and scale it while game running.

You can go to the project properties → game and resolution switch to the option “no antialising”, then you will be able to resize any object in your game without having issues with blur.