Short answer: Yes!
Gameplay wise, yes you can do pretty much anything but not all kind of 2d staff, there are limitations that you need to consider if you need them or not. For example lighting and shadow effects are pretty limited in GD in case you plan to use nice and polished lighting effects, you may find GD a bit “outdated”.
Also you won’t be able to make fluid and cloth simulation for example and online multiplayer game is a big question mark as the networking extension is obsolete but not a word about the future.
Also in case you plan to publish your game on mobile or Microsoft store and add in-app purchase, it is not possible at the moment so you won’t be able to. You can ad AdSense banner to your HTML5 game but people report problems all the time and I don’t think it worth it anyway. In case you want to make money your only real option is to sell your game.
Game Maker Studio is the most complete game development tool out there today. It got most features that people need and support most platform and it got a huge community with lot of tutorials and info. Of course it got it limitations and bugs but overall it a better engine, technically speaking there is nothing that GDevelop can offer over GMS. Personally I find the IDE and the content management of GD superior compared to most other tools out there but the actual engine under the hood sometime feels a bit outdated to be honest because of the above limitations but overall it is a solid engine that is capable to support a minimalistic and solid games but no fancy visual effects and pro features I’m afraid.
I haven’t played Risk of Rain but I did watch some gameplay on youtube and from what I can see it perfectly doable in GDevelop but in case you do have experience with GMS and you have no problems with limitations or scripting then you might need to consider to stick to GMS. Yes it is awful expensive but for that price you get a professional tool and support while GDevelop is more of a hobbyist tool with no support at all. So I don’t recommend to drop GMS only because of the price tag. Only last year it was on Humble Bundle at least twice that I know of and it is on sale every few months too . Also the price might drop when GMS 2 is out of beta.
Regarding “control over lag”, if you are having problems with performance and lag in GMS and that’s why you want to replace it, I don’t think you get more control and better performance with GDevelop. It might be a slightly faster and better in HTML5 and about the same on Windows and Linux but you definitely get more lag and trouble with GD on mobile devices.
The only way I can recommend GDevelop over GMS if you find GMS difficult to use or you just looking for a simple, easy and quick way to make 2D games.
But in case you want to replace GMS only because of the price tag or performance, I don’t think it worth it.